# The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review

## TL;DR

This review explores how kidney cancer can cause skin issues, highlighting the role of cellular stress and how recognizing these skin signs may help detect kidney cancer early.

## Contribution

The paper introduces a narrative framework linking cellular stress responses to cutaneous manifestations in renal cell carcinoma.

## Key findings

- Cellular stress is proposed as a key driver of skin manifestations in distant cancers like renal cell carcinoma.
- Cutaneous complications are categorized into malignant, non-malignant, and treatment-related types.
- Early recognition of skin disorders may improve prognosis by aiding early detection of kidney cancer.

## Abstract

The carcinomas originating from the renal cortex are the most aggressive renal malignancies, with a high tendency for metastasis. Understanding the incidence of cutaneous manifestations caused by renal carcinomas is a challenge. In the first part, this article summarizes a series of factors that promote oncogenesis, invasiveness, and the ability of renal cell carcinoma (RCC) to develop secondary cutaneous manifestations. It is postulated that the cellular stress response is one of the leading causes of developing dermatological events induced by cancers located at distant sites. Furthermore, the paper provides an overview of cutaneous complications associated with renal cancer, categorized as malignant manifestations (metastases, synchronous or metachronous cutaneous malignancies associated with renal cancer), non-malignant indirect cutaneous manifestations associated with renal cancer, and treatment consequences. The data presented in this article suggest that recognizing certain cutaneous disorders could assist the physician in the early identification of renal neoplasms and could lead to a better prognosis.