# Tapping into Nature’s Arsenal: Harnessing the Potential of Natural Antioxidants for Human Health and Disease Prevention

## TL;DR

Natural antioxidants in our diet can help prevent diseases by fighting harmful molecules, but more research is needed to understand how best to use them in combination for maximum benefit.

## Contribution

The paper proposes that combining multiple natural antioxidants may be more effective than using single compounds for disease prevention and treatment.

## Key findings

- Natural antioxidants show antihypertensive, anti-inflammatory, and anticancer effects in preclinical studies.
- Combining antioxidants may enhance their therapeutic potential compared to monotherapies.
- Clinical evidence supports their role in preventing non-alcoholic fatty liver disease and ischemia-reperfusion-related conditions.

## Abstract

Numerous natural antioxidants commonly found in our daily diet have demonstrated significant benefits for human health and various diseases by counteracting the impact of reactive oxygen and nitrogen species. Their chemical properties enable a range of biological actions, including antihypertensive, antimicrobial, anti-inflammatory, anti-fibrotic, and anticancer effects. Despite promising outcomes from preclinical studies, ongoing debate persists regarding their reproducibility in human clinical models. This controversy largely stems from a lack of understanding of the pharmacokinetic properties of these compounds, coupled with the predominant focus on monotherapies in research, neglecting potential synergistic effects arising from combining different antioxidants. This study aims to provide an updated overview of natural antioxidants, operating under the hypothesis that a multitherapeutic approach surpasses monotherapy in efficacy. Additionally, this study underscores the importance of integrating these antioxidants into the daily diet, as they have the potential to prevent the onset and progression of various diseases. To reinforce this perspective, clinical findings pertaining to the treatment and prevention of non-alcoholic fatty liver disease and conditions associated with ischemia and reperfusion phenomena, including myocardial infarction, postoperative atrial fibrillation, and stroke, are presented as key references.