# Assessment of the Impact of Trace Essential Metals on Cancer Development

**Authors:** Aleksandra Górska, Agnieszka Markiewicz-Gospodarek, Mateusz Trubalski, Marta Żerebiec, Julia Poleszak, Renata Markiewicz

PMC · DOI: 10.3390/ijms25136842 · International Journal of Molecular Sciences · 2024-06-21

## TL;DR

This study explores how trace essential metals like zinc and copper can both promote and inhibit cancer development, offering insights into cancer mechanisms and potential treatments.

## Contribution

The study provides a comprehensive analysis of the dual roles of essential trace metals in cancer progression.

## Key findings

- Zinc, copper, cobalt, iron, and manganese have multifaceted effects on cancer development.
- These metals influence cell proliferation, angiogenesis, and metastasis.
- Understanding their roles could lead to new biomarkers and therapeutic targets.

## Abstract

This study examines the impact of zinc, copper, cobalt, iron, and manganese on cancer development, considering their dual roles as potential promoters or inhibitors within tumorigenesis. A comprehensive analysis of existing literature and experimental data is conducted to elucidate the intricate relationship between these trace elements and cancer progression. The findings highlight the multifaceted effects of zinc, copper, cobalt, iron, and manganese on various aspects of cancer development, including cell proliferation, angiogenesis, and metastasis. Understanding the nuanced interactions between these trace elements and cancer could offer crucial insights into tumorigenesis mechanisms and facilitate the identification of novel biomarkers and therapeutic targets for cancer prevention and treatment strategies. This research underscores the importance of considering the roles of essential trace elements in cancer biology and may ultimately contribute to advancements in precision medicine approaches for combating cancer.

## Linked entities

- **Chemicals:** zinc (PubChem CID 23994), copper (PubChem CID 23978), cobalt (PubChem CID 104730), iron (PubChem CID 23925), manganese (PubChem CID 23930)
- **Diseases:** cancer (MONDO:0004992)

## Full-text entities

- **Diseases:** Cancer (MESH:D009369), tumorigenesis (MESH:D063646), metastasis (MESH:D009362)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11241304/full.md

## References

112 references — full list in the complete paper: https://tomesphere.com/paper/PMC11241304/full.md

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Source: https://tomesphere.com/paper/PMC11241304