# Case Report: Could topical epidermal growth factor be considered a new therapy for skin injuries in premature infants?

**Authors:** F. Cossovel, F. Marrazzo, S. Nider, A. Traunero, G. Dussi, L. Travan, M. Cirino, D. Zanon

PMC · DOI: 10.3389/fped.2024.1424191 · 2024-06-28

## TL;DR

A premature infant's skin injury healed completely after using a new topical treatment with epidermal growth factor when standard methods failed.

## Contribution

This case suggests that topical epidermal growth factor may be an effective therapy for skin injuries in premature infants.

## Key findings

- A pressure injury on a premature infant's nose healed completely after using a topical epidermal growth factor treatment.
- Standard therapies failed to improve the injury, but the new treatment was successful.
- The case supports the potential of epidermal growth factor as a novel therapy for neonatal skin injuries.

## Abstract

In this case report, we present the experience of a premature neonate born at 28 weeks of gestation who, following prolonged respiratory support, developed a pressure injury on the columella despite the implementation of all appropriate preventive techniques. This injury did not improve with standard therapies; therefore, it was necessary to apply a topical galenic therapy containing epidermal growth factor, resulting in complete healing of the lesion.

## Full-text entities

- **Genes:** EGF (epidermal growth factor) [NCBI Gene 1950] {aka HOMG4, URG}
- **Diseases:** skin injuries (MESH:D000069836), pressure injury (MESH:D003668)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11239408/full.md

---
Source: https://tomesphere.com/paper/PMC11239408