Guillain-Barre Syndrome as an Atypical Early Presentation of Adult-Onset Still's Disease: A Case Report

TL;DR

A patient with Guillain-Barre Syndrome was later diagnosed with Adult-Onset Still's Disease, a rare inflammatory disorder.

Contribution

This is the first reported case of Guillain-Barre Syndrome as an early presentation of Adult-Onset Still's Disease.

Findings

Guillain-Barre Syndrome can be an atypical early sign of Adult-Onset Still's Disease.

The patient showed improvement with corticosteroid therapy after diagnosis.

Abstract

Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disorder with unknown pathophysiology. Although having a heterogeneous clinical spectrum, the major features of AOSD include fever, rash, and arthritis or arthralgia. Neurological involvement is rare in AOSD with aseptic meningitis being the most common presentation. Guillain-Barre syndrome (GBS) has never been reported as an early presentation of AOSD. Herein, we describe the case of a patient presenting with GBS and fever of unknown origin who was soon diagnosed with AOSD and improved with corticosteroid therapy.

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