Nanocatalytic NO gas therapy against orthotopic oral squamous cell carcinoma by single iron atomic nanocatalysts
Yuting Xie, Jiaxin Zuo, Angang Ding, Ping Xiong
TL;DR
Researchers developed a new cancer treatment using iron-based nanocatalysts that release nitric oxide gas to kill oral cancer cells with high selectivity and biocompatibility.
Contribution
The study introduces single-atom iron nanocatalysts modified with a nitric oxide donor for synergistic cancer therapy.
Findings
NIR laser triggers nitric oxide release and hydroxyl radical generation for tumor cell death.
The treatment shows high therapeutic selectivity and efficacy against orthotopic oral cancer.
The nanocatalytic approach demonstrates strong biocompatibility and antitumor potential.
Abstract
Oral squamous cell carcinoma (OSCC) has been being one of the most malignant carcinomas featuring high metastatic and recurrence rates. The current OSCC treatment modalities in clinics severely deteriorate the quality of life of patients due to the impaired oral and maxillofacial functions. In the present work, we have engineered the single-atom Fe nanocatalysts (SAF NCs) with a NO donor (S-nitrosothiol, SNO) via surface modification to achieve synergistic nanocatalytic NO gas therapy against orthotopic OSCC. Upon near-infrared laser irradiation, the photonic hyperthermia could effectively augment the heterogeneous Fenton catalytic activity, meanwhile trigger the thermal decomposition of the engineered NO donor, thus producing toxic hydroxyl radicals (•OH) and antitumor therapeutic NO gas at tumor lesion simultaneously, and consequently inducing the apoptotic cell death of tumors via…
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Taxonomy
TopicsTechnology and Human Factors in Education and Health · Transportation Systems and Logistics · Aerospace, Electronics, Mathematical Modeling