# Primary retroperitoneal müllerian adenocarcinoma: a case report

## TL;DR

A rare case of primary retroperitoneal müllerian adenocarcinoma is reported in a 45-year-old woman with metastases and confirmed through biopsy and immunohistochemistry.

## Contribution

This case report adds to the limited literature on primary retroperitoneal müllerian adenocarcinoma, highlighting its diagnostic features.

## Key findings

- The tumor was confirmed as primary retroperitoneal müllerian adenocarcinoma through biopsy and immunohistochemical analysis.
- Immunohistochemistry showed positive keratin7 and PAX8, with negative markers for other common tumors.
- The case highlights the importance of considering PRMA in retroperitoneal mass diagnoses.

## Abstract

A 45-year-old woman presented with right hip pain for a month. Imaging results revealed that the left peritoneal mass was accompanied by metastases of the right sciatic branch, lung, and retroperitoneal lymph nodes. A biopsy of the left peritoneal mass was performed. The pathological morphology demonstrated clear cell adenocarcinoma. Immunohistochemical staining revealed a positive expression of keratin7 and PAX8 and a negative expression of keratin20, GCDFP-15, ER, PR, WT1, CDX2, villin, TTF-1, napsin-A, vimentin, calretinin, and GATA3. Finally, the diagnosis of primary retroperitoneal müllerian adenocarcinoma (PRMA) was confirmed. PRMA is a very rare type of primary retroperitoneal tumor. PRMA should be considered for the retroperitoneal mass.