# COVID-19 Infection and ST-Elevation Myocardial Infarction: Lessons in Disease Management During a Pandemic

**Authors:** Anna Carmichael, Joseph T Hale, Shahnawaz Notta, Tariq Haddadin, Manar H Jbara

PMC · DOI: 10.7759/cureus.62008 · 2024-06-09

## TL;DR

This paper discusses how a 61-year-old man with a history of high cholesterol developed a severe heart attack shortly after being treated for COVID-19, highlighting the increased cardiovascular risks during the pandemic.

## Contribution

The study emphasizes the heightened risk of STEMI in post-COVID-19 patients and the challenges in managing concurrent conditions.

## Key findings

- A case of STEMI occurred shortly after discharge from COVID-19 treatment in a patient with hyperlipidemia.
- SARS-CoV-2 can induce a prothrombotic state, leading to endothelial dysfunction and systemic inflammation.
- Timely intervention, such as PCI, is crucial for managing concurrent STEMI and COVID-19.

## Abstract

The emergence of the SARS-CoV-2 virus, causing the COVID-19 pandemic, has profoundly impacted global health, resulting in significant morbidity and mortality worldwide. This paper presents a case study highlighting the heightened risk of severe cardiovascular complications following COVID-19 infection. A 61-year-old male with hyperlipidemia was discharged after COVID-19 pneumonia treatment and experienced a severe ST-elevated myocardial infarction (STEMI) within a day of discharge. A retrospective chart review, supplemented by a literature review, revealed a pattern of increased severity in STEMI cases associated with COVID-19, particularly in patients with pre-existing cardiovascular comorbidities. SARS-CoV-2 induces a prothrombotic state, which causes endothelial dysfunction and systemic inflammation, potentially precipitating thrombotic events. Managing concurrent COVID-19 and STEMI poses unique challenges, emphasizing the critical role of timely intervention, such as percutaneous coronary intervention (PCI), in improving patient outcomes. Despite advancements, uncertainty persists regarding optimal thromboembolism prophylaxis post COVID-19, necessitating ongoing research and meticulous clinical management. While COVID-19 infection rates have declined since the pandemic, this case report hopes to emphasize the need for continued awareness in recognizing the potential thrombotic risks of COVID-19 infection and underscore the need for further investigation into cardiovascular risk as new viral strains develop in the future.

## Linked entities

- **Diseases:** hyperlipidemia (MONDO:0021187), STEMI (MONDO:0041656), SARS-CoV-2 (MONDO:0100096), COVID-19 (MONDO:0100096), pneumonia (MONDO:0005249)

## Full-text entities

- **Diseases:** ST-Elevation Myocardial Infarction (MESH:D000072657), COVID-19 (MESH:D000086382), hyperlipidemia (MESH:D006949), thromboembolism (MESH:D013923), cardiovascular complications (MESH:D002318), inflammation (MESH:D007249), endothelial dysfunction (MESH:D014652), thrombotic (MESH:D013927)
- **Species:** Homo sapiens (human, species) [taxon 9606], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11233153/full.md

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Source: https://tomesphere.com/paper/PMC11233153