# Infiltrative Basal Cell Carcinoma (iBCC) Adjacent to a Desmoplastic Trichoepithelioma (DTE): A Case Report and Literature Review of iBCCs and DTEs

## TL;DR

A rare case of infiltrative basal cell carcinoma and desmoplastic trichoepithelioma co-occurring in a single skin lesion is reported, emphasizing the importance of accurate diagnosis.

## Contribution

The paper presents a unique case of co-occurring iBCC and DTE and reviews literature on their potential genetic links.

## Key findings

- A 36-year-old female had a skin lesion containing both iBCC and DTE confirmed by histopathology.
- Collision tumors of iBCC and DTE are rare and require careful differentiation due to differing clinical outcomes.
- The paper discusses possible genetic connections between iBCC and DTE based on literature review.

## Abstract

The co-existence of an infiltrative basal cell carcinoma (iBCC) and a desmoplastic trichoepithelioma (DTE) within the same cutaneous lesion is a rare occurrence. iBCCs are relatively common malignant skin neoplasms that pose a risk for local tissue destruction and recurrence. DTEs are cutaneous neoplasms originating from hair follicles that may clinically and histologically appear similar to iBCCs but are ultimately benign. Distinguishing between these two entities is important given their differing destructive potential. Herein, we describe the case of a 36-year-old female with a single skin lesion on her left cheek that was comprised of both an iBCC distinct from a DTE, as verified by histopathologic analysis. A literature review highlights the rarity of such collision tumors and discusses the potential genetic links between these two histologically similar cutaneous neoplasms.