# Fibrillary Glomerulonephritis Leading to End-Stage Renal Disease in the Absence of Active or Chronic Hepatitis C Infection: Current Insights

## TL;DR

A patient developed kidney disease linked to past Hepatitis C infection, even though the virus was no longer active.

## Contribution

This case highlights a possible link between cleared Hepatitis C infection and FGN development.

## Key findings

- A patient with undetectable Hepatitis C viral load developed FGN.
- Renal biopsy showed FGN with DNAJB9 staining.
- The case suggests a potential association between resolved Hepatitis C and FGN.

## Abstract

Fibrillary glomerulonephritis (FGN) is a rare glomerular disease with various etiologies, including idiopathic cases and associations with autoimmune diseases, neoplasms, and viral infections, such as Hepatitis C. We present a case of a patient who developed acute kidney injury (AKI) with atypical clinical features. A subsequent renal biopsy confirmed the diagnosis of FGN, with distinct immunofluorescence staining for DNAJB9. The patient tested positive for Hepatitis C antibodies with an undetectable viral load, indicating a past infection that had self-cleared. This finding prompted further investigation of the association between Hepatitis C and the development of FGN.