# A Case of Alveolar Rhabdomyosarcoma of the Nasal Cavity in an Adult: An Unusual Location

**Authors:** Hajar El Bakouri, Oumayma Mezouari, Wafaa Merssetti, Mariame Harrak, Niama Ghozali, Hamza Zerbani, Nabila Sellal, Mohamed Elhfid

PMC · DOI: 10.7759/cureus.61815 · Cureus · 2024-06-06

## TL;DR

This paper reports a rare case of alveolar rhabdomyosarcoma in an adult's nasal cavity, highlighting the challenges in treating this aggressive cancer.

## Contribution

The novelty lies in documenting an unusual presentation and treatment course of alveolar rhabdomyosarcoma in an adult with a history of breast cancer.

## Key findings

- The patient showed partial response to initial chemotherapy followed by chemoradiotherapy.
- The cancer progressed to metastasis after 18 months despite treatment.
- The case underscores the poor prognosis and lack of standardized treatment for adult alveolar rhabdomyosarcoma.

## Abstract

Rhabdomyosarcoma is a common soft tissue tumor in children but rare in adults. Alveolar rhabdomyosarcoma represents a subtype of rhabdomyosarcoma, extremely rare in adults, especially within the nasal cavities. Therapeutic protocols for adults are often based on those used in pediatric cases.

We present the case of a 56-year-old female patient with a history of breast cancer who developed alveolar rhabdomyosarcoma of the nasal cavity, stage III, managed initially with chemotherapy resulting in partial response. Subsequently, the patient underwent concomitant chemoradiotherapy. The clinical course was marked by local remission with metastatic progression after 18 months.

Alveolar rhabdomyosarcoma is uncommon in adults, and its therapeutic management remains non-standardized. However, it is typically based on initial chemotherapy followed by local treatment.

Despite therapeutic advances, the prognosis remains poor.

## Linked entities

- **Diseases:** alveolar rhabdomyosarcoma (MONDO:0009994), breast cancer (MONDO:0004989)

## Full-text entities

- **Diseases:** soft tissue tumor (MESH:D012983), breast cancer (MESH:D001943), Alveolar Rhabdomyosarcoma of the Nasal Cavity (MESH:D018232), Rhabdomyosarcoma (MESH:D012208)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11227285/full.md

## References

28 references — full list in the complete paper: https://tomesphere.com/paper/PMC11227285/full.md

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Source: https://tomesphere.com/paper/PMC11227285