# An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus an aminoglycoside + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial—an update to the published protocol

## TL;DR

This paper updates the protocol for a clinical trial comparing ciprofloxacin alone versus ciprofloxacin plus an aminoglycoside for treating bubonic plague.

## Contribution

The paper provides an updated protocol for a clinical trial evaluating treatment efficacy and safety for bubonic plague.

## Key findings

- The trial protocol was prospectively registered on clinicaltrials.gov.
- The study is an open-label, randomized, non-inferiority trial comparing two treatment regimens.

## Abstract

This article reports an update to the protocol of the IMASOY trial, which was prospectively registered on clinicaltrials.gov (NCT04110340) in October 2019.