# Laparoscopy is non‐inferior to open surgery for rectal cancer: A systematic review and meta‐analysis

## TL;DR

Laparoscopic surgery for rectal cancer is as effective as open surgery in the long term and offers faster recovery and fewer complications in the short term.

## Contribution

This is the largest meta-analysis to date showing laparoscopy is non-inferior to open surgery for rectal cancer.

## Key findings

- Laparoscopic surgery reduced 30-day mortality, complications, and recovery time compared to open surgery.
- Laparoscopy showed lower positive circumferential and distal margin rates, with no difference in mesorectal excision completeness.
- Laparoscopic surgery improved 3- and 5-year local recurrence, disease-free survival, and overall survival.

## Abstract

Laparoscopic surgery has been endorsed by clinical guidelines for colon cancer, but not for rectal cancer on account of unapproved oncologic equivalence with open surgery.

We started this largest‐to‐date meta‐analysis to comprehensively evaluate the safety and efficacy of laparoscopy in the treatment of rectal cancer compared with open surgery.

Both randomized and nonrandomized controlled trials comparing laparoscopic proctectomy and open surgery between January 1990 and March 2020 were searched in PubMed, Cochrane Library and Embase Databases (PROSPERO registration number CRD42020211718). The data of intraoperative, pathological, postoperative and survival outcomes were compared between two groups.

Twenty RCTs and 93 NRCTs including 216,615 patients fulfilled the inclusion criteria, with 48,888 patients received laparoscopic surgery and 167,727 patients underwent open surgery. Compared with open surgery, laparoscopic surgery group showed faster recovery, less complications and decreased mortality within 30 days. The positive rate of circumferential margin (RR = 0.79, 95% CI: 0.72 to 0.85, p < 0.0001) and distal margin (RR = 0.75, 95% CI: 0.66 to 0.85 p < 0.0001) was significantly reduced in the laparoscopic surgery group, but the completeness of total mesorectal excision showed no significant difference. The 3‐year and 5‐year local recurrence, disease‐free survival and overall survival were all improved in the laparoscopic surgery group, while the distal recurrence did not differ significantly between the two approaches.

Laparoscopy is non‐inferior to open surgery for rectal cancer with respect to oncological outcomes and long‐term survival. Moreover, laparoscopic surgery provides short‐term advantages, including faster recovery and less complications.