# Exploring Marchiafava-Bignami Disease: A Rare Presentation in a Young Pregnant Female

## TL;DR

A 30-year-old pregnant woman with no alcohol history was diagnosed with Marchiafava-Bignami disease and improved with thiamine treatment.

## Contribution

Reports a rare case of MBD in a non-alcoholic, young pregnant woman with nutritional deficiency.

## Key findings

- MRI findings were consistent with Marchiafava-Bignami disease in a non-alcoholic patient.
- High-dose intravenous thiamine led to a significant clinical improvement.
- The patient had symptoms of confusion and speech issues linked to the disease.

## Abstract

Marchiafava-Bignami disease (MBD) is uncommon and typically linked with persistent alcohol consumption; nevertheless, instances have been reported in non-alcoholic individuals with nutritional deficiencies. Depending on the severity, this condition may manifest as acute, subacute, or chronic neurological signs and symptoms, ranging from moderate dysarthria or mild disorientation to coma and death. We report a case of a 30-year-old, 14-week pregnant female who presented with complaints of persistent vomiting and loss of appetite. She was found to have achalasia cardia on upper GI endoscopy. Later, she developed confusion, irrelevant talks and her speech was incomprehensible. An MRI of the brain was done which showed features likely that of MBD. She was started high dose intravenous thiamine to which she responded brilliantly.