# A Case of an Autoimmune Blistering Disease: Pemphigus Vulgaris

## TL;DR

This paper presents a case of pemphigus vulgaris, a rare autoimmune blistering disease, highlighting the importance of accurate diagnosis and treatment to prevent worsening symptoms.

## Contribution

The novelty lies in reporting a real-life case emphasizing the clinical presentation and treatment of pemphigus vulgaris to prevent misdiagnosis.

## Key findings

- The patient was misdiagnosed initially and experienced worsening symptoms due to delayed treatment.
- Diagnosis was confirmed via punch biopsies and direct immunofluorescence.
- Treatment with prednisone and mycophenolate mofetil led to symptom clearance.

## Abstract

Pemphigus vulgaris is a rare autoimmune disorder characterized by the formation of intraepithelial blisters that clinically appear as erosions and flaccid bullae on the skin and mucus membranes. Herein, we report a case of pemphigus vulgaris in an elderly male. He was initially misdiagnosed by his primary care provider and given topical lidocaine and acetaminophen with hydrocodone, without improvement in symptoms. This delay in treatment caused a worsening of his condition. The patient presented to our dermatology office two months after his primary care visit and reported worsening blisters and pain. Clinically he presented with flaccid bullae, crusted erosions, and erythematous plaques on the chest, back, abdomen, arms, and legs, and a tender oral ulcer. Two punch biopsies were obtained and sent for direct immunofluorescence and routine histology. The biopsy results confirmed the diagnosis of pemphigus vulgaris. Our patient achieved clearance after four weeks of oral prednisone and maintained clearance after a slow prednisone taper and the addition of mycophenolate mofetil 1g twice daily. We aim to bring awareness of the clinical presentation and treatment regimen of pemphigus vulgaris to prevent misdiagnosis and delayed care.