# An Unusual Case of Fever in Paralytic Ileus

**Authors:** Shubhangi Kanitkar, Sai Priya Ande, Prasad Bagare, Akshata Borle, Muskaan Ahlawat

PMC · DOI: 10.7759/cureus.61671 · Cureus · 2024-06-04

## TL;DR

A 19-year-old man with high fever and paralytic ileus was treated successfully with steroids and cyclophosphamide, suggesting a rare autoimmune condition.

## Contribution

This case highlights an unusual presentation of Still's disease and its management with immunosuppressive therapy.

## Key findings

- The patient showed rapid improvement with intravenous glucocorticoids and cyclophosphamide.
- Tofacitinib was initiated during follow-up based on clinical response.
- The case suggests an autoimmune origin for the fever and ileus.

## Abstract

Still's disease is frequently a condition of exclusion for patients with an unidentified cause of fever. Accompanying symptoms typically include fever, arthralgia, and a transient skin rash. The underlying pathophysiology indicates an autoimmune origin. Diagnosis is primarily clinical, often utilizing the Yamaguchi criteria. The case in question involves a 19-year-old male presenting with high-grade fever and paralytic ileus. The patient received intravenous glucocorticoids and cyclophosphamide, resulting in a rapid clinical improvement. During the follow-up, tofacitinib was initiated based on the clinical response observed.

## Linked entities

- **Chemicals:** cyclophosphamide (PubChem CID 2907), tofacitinib (PubChem CID 9926791)
- **Diseases:** paralytic ileus (MONDO:0004568)

## Full-text entities

- **Diseases:** Fever (MESH:D005334), Paralytic Ileus (MESH:D007418), arthralgia (MESH:D018771), Still's disease (MESH:D016706), skin rash (MESH:D005076)
- **Chemicals:** cyclophosphamide (MESH:D003520), tofacitinib (MESH:C479163)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11223741/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC11223741/full.md

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Source: https://tomesphere.com/paper/PMC11223741