# A Case Report on a Rare Type of Lymphoma: Angioimmunoblastic T-cell Lymphoma

**Authors:** Andreia S Machado, Ana Catarina B Marques, Antony Soares Dionísio, Beatriz S Ferreira, Tiago M Marques

PMC · DOI: 10.7759/cureus.61670 · Cureus · 2024-06-04

## TL;DR

This case report describes a rare T-cell lymphoma in a 60-year-old woman with delayed diagnosis and poor outcome.

## Contribution

The paper highlights the diagnostic challenges and clinical course of angioimmunoblastic T-cell lymphoma through a detailed case report.

## Key findings

- The patient presented with nonspecific symptoms like fatigue, fever, and weight loss, delaying diagnosis.
- Histology confirmed angioimmunoblastic T-cell lymphoma after inconclusive initial tests.
- The patient's condition progressed despite treatment, leading to death within six months.

## Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is a rare type of non-Hodgkin lymphoma (NHL). We present a case of a 60-year-old female who attended the emergency department (ED) with fatigue, recurrent fever, weight loss, and adenopathy for six months. Laboratory findings showed anemia, lymphocytosis, eosinophilia, thrombocytosis, cholestasis, hypoproteinemia, and hypoalbuminemia. Abdominopelvic computed tomography (CT) revealed multiple adenopathies. A lymph node biopsy yielded inconclusive results in the outpatient clinic. Later, during admission, the patient underwent a positron emission tomography-computed tomography (PET-CT), revealing a cervical adenopathy cluster that was excised en bloc. Histology confirmed the diagnosis of AITL. The medical team initiated chemotherapy but opted for exclusive symptomatic treatment due to disease progression. The patient died six months after diagnosis. The fluctuating and nonspecific presentation of AITL can hinder and delay definitive diagnosis, therefore impacting treatment and prognosis.

## Linked entities

- **Diseases:** Angioimmunoblastic T-cell Lymphoma (MONDO:0004977), non-Hodgkin lymphoma (MONDO:0018908)

## Full-text entities

- **Diseases:** adenopathies (MESH:D000072281), weight loss (MESH:D015431), hypoalbuminemia (MESH:D034141), Lymphoma (MESH:D008223), eosinophilia (MESH:D004802), died (MESH:D003643), anemia (MESH:D000740), cholestasis (MESH:D002779), AITL (MESH:D016399), hypoproteinemia (MESH:D007019), thrombocytosis (MESH:D013922), lymphocytosis (MESH:D008218), fatigue (MESH:D005221), fever (MESH:D005334), NHL (MESH:D008228)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11223733/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC11223733/full.md

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Source: https://tomesphere.com/paper/PMC11223733