# A Case Presentation of Well-Differentiated Hepatocellular Carcinoma With No Sign of Liver Disease

## TL;DR

This paper presents a rare case of liver cancer in an elderly man with no history of liver disease or risk factors.

## Contribution

The novelty is the presentation of a well-differentiated HCC case without typical underlying liver disease.

## Key findings

- The patient had no etiological factors for HCC such as alcohol or viral hepatitis.
- The cancer showed well-differentiated features with minimal nuclear atypia.
- The case highlights the possibility of HCC without traditional risk factors.

## Abstract

The type of liver cancer that occurs most frequently is hepatocellular carcinoma (HCC). The majority of cases of HCC are secondary to alcoholic cirrhosis or viral hepatitis. The presence of malignant cells with modest nuclear atypia that resemble normal hepatocytes and the lack of bare nuclei in the smears, which shows the neoplastic hepatocytes' capacity, are characteristics of a well-differentiated HCC plasma membrane to tolerate smearing. We present the case of an 83-year-old male patient with a well-differentiated HCC, who had no etiological factors and no signs of alcohol cirrhotic liver, or any symptoms of liver disease which are the main causes of the HCC.