# The Effect of Targeted Temperature Therapy on Antioxidant Levels in Patients With Spontaneous Circulation After Cardiac Arrest

## TL;DR

This study examines how targeted temperature therapy affects antioxidant levels in cardiac arrest patients who regain spontaneous circulation.

## Contribution

The study provides new insights into the impact of TTM on oxidative stress markers in post-cardiac arrest patients.

## Key findings

- TAS and TOS levels decreased significantly by the end of 48-hour TTM therapy.
- Nrf-2 and OSI levels showed no statistically significant changes during TTM.
- Oxidant-antioxidant balance was preserved in patients receiving TTM.

## Abstract

Introduction

In this study, we aimed to measure the change in total antioxidant status (TAS), total oxidant stress (TOS), oxidative stress index (OSI), and nuclear factor erythroid 2 (Nrf-2) levels during the treatment period in patients who restored spontaneous circulation return after cardiac arrest with targeted temperature management (TTM) therapy in our hospital.

Methods

The study included 36 patients who were hospitalized in the anesthesia intensive care unit and coronary intensive care unit of our hospital and were treated with TTM therapy after cardiac arrest. TAS, TOS, OSI, and Nrf-2 levels were measured at 0 (beginning), 12, 24, and 48 (end) hours of TTM therapy.

Results

The mean age of the patients participating in the study was 54.25±17.10. TAS and TOS levels decreased gradually during TTM therapy, but statistically significant decrease was observed at the end of the hour. When Nrf-2 and OSI levels were evaluated, it was found that no statistically significant difference was observed during the TTM therapy.

Conclusion

In our study, the oxidant-antioxidant balance was preserved in patients who received TTM therapy after cardiac arrest. We predict TTM therapy is effective on oxidative stress after cardiac arrest and should be applied for at least 48 hours.