# Schwannoma in the Rectum: A Case Report

**Authors:** Mikayla Hobbs, Ryan Denis, Martin Felix, Marianna Zeichen

PMC · DOI: 10.7759/cureus.61571 · Cureus · 2024-06-03

## TL;DR

A 60-year-old woman was diagnosed with a rare rectal schwannoma, highlighting the need to consider this condition in rectal mass cases.

## Contribution

This paper presents a rare case of rectal schwannoma and emphasizes its inclusion in differential diagnoses.

## Key findings

- A rectal mass was identified in a patient with no dysplasia or malignancy on preoperative biopsy.
- Immunohistochemistry confirmed the mass as a schwannoma, positive for SOX10 and S100.
- The case underscores the importance of considering schwannomas in rectal mass differential diagnoses.

## Abstract

A woman in her 60s with a past medical history of recurrent Helicobacter pylori (H. pylori) presented for surgical consultation after a colonoscopy revealed a mass in the rectum. Preoperative biopsy revealed mucosal excrescence with no dysplasia or malignant changes. The final pathology showed a solid, submucosal rectal mass that was positive for SOX10 and S100 on immunohistochemistry, supporting our diagnosis of Schwannoma. This case emphasizes the importance of considering schwannomas in the differential diagnosis of patients presenting with a rectal mass no matter how rare it may be.

## Linked entities

- **Proteins:** SOX10 (SRY-box transcription factor 10), S100A1 (S100 calcium binding protein A1)

## Full-text entities

- **Genes:** S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}, SOX10 (SRY-box transcription factor 10) [NCBI Gene 6663] {aka DOM, PCWH, SOX-10, WS2E, WS4, WS4C}
- **Diseases:** Schwannoma (MESH:D009442), dysplasia (MESH:D015792), rectal mass (MESH:D012002)
- **Species:** Helicobacter pylori (species) [taxon 210], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11221193/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC11221193/full.md

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Source: https://tomesphere.com/paper/PMC11221193