Iron gallic acid biomimetic nanoparticles for targeted magnetic resonance imaging
Yan Chen, Zhaohui Zhang, Zhijian Chen, Shiqing Jiang, Aikebaier Reheman, Yifan Ouyang, Bo Yu, Qiuyan Chen, Dingtai Wei
TL;DR
Researchers developed a new MRI contrast agent using iron-gallic acid nanoparticles coated with cell membranes to improve targeting and safety in glioma imaging.
Contribution
The novel use of biomimetic cell membrane-coated iron-gallic acid nanoparticles for targeted T1-weighted MRI is introduced.
Findings
Fe–GA nanoparticles at an 8:1 mass ratio showed effective T1-weighted MRI contrast.
T98G CM-coated NPs demonstrated improved glioma targeting in vitro.
The biomimetic strategy shows potential for safe and effective theranostic agents.
Abstract
Developing T1-weighted magnetic resonance imaging (MRI) contrast agents with enhanced biocompatibility and targeting capabilities is crucial owing to concerns over current agents’ potential toxicity and suboptimal performance. Drawing inspiration from “biomimetic camouflage,” we isolated cell membranes (CMs) from human glioblastoma (T98G) cell lines via the extrusion method to facilitate homotypic glioma targeting. At an 8:1 mass ratio of ferric chloride hexahydrate to gallic acid (GA), the resulting iron (Fe)–GA nanoparticles (NPs) proved effective as a T1-weighted MRI contrast agent. T98G CM–coated Fe–GA NPs demonstrated improved homotypic glioma targeting, validated through Prussian blue staining and in vitro MRI. This biomimetic camouflage strategy holds promise for the development of targeted theranostic agents in a safe and effective manner.
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Taxonomy
TopicsNanoparticle-Based Drug Delivery · Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics