# RETRACTION: Six2 Promotes Non–Small Cell Lung Cancer Cell Stemness Via Transcriptionally and Epigenetically Regulating E‐Cadherin

PMC · DOI: 10.1111/cpr.13682 · 2024-05-28

## TL;DR

This retracted study claimed that Six2 promotes lung cancer cell stemness by regulating E-Cadherin, but the findings are considered unreliable.

## Contribution

The paper was retracted due to unreliable results and lack of original data, highlighting the importance of data integrity in scientific research.

## Key findings

- The article was retracted due to unreliable results and lack of original data.
- Multiple images were found to have been previously published elsewhere in a different context.

## Abstract

H. Hou, X. Yu, P. Cong, Y. Zhou, Y. Xu, Y. Jiang, “Six2 Promotes Non–Small Cell Lung Cancer Cell Stemness Via Transcriptionally and Epigenetically Regulating E‐Cadherin,” Cell Proliferation 52, no. 4 (2019): e12617, https://doi.org/10.1111/cpr.12617

The above article, published online on 22 April 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Deputy Editor‐in‐Chief, Yunfeng Lin, and John Wiley and Sons Ltd. The retraction has been agreed following the authors' request to retract the article due to unreliable results and a lack of original data. Further investigation revealed multiple images previously published elsewhere in a different scientific context. Thus, the editors consider the conclusions of this manuscript substantially compromised. The corresponding author Yuhua Jiang agrees with this decision on behalf of all authors.

## Linked entities

- **Genes:** SIX2 (SIX homeobox 2) [NCBI Gene 10736], shg (shotgun) [NCBI Gene 37386]
- **Diseases:** Non–Small Cell Lung Cancer (MONDO:0005233)

## Full-text entities

- **Genes:** SIX2 (SIX homeobox 2) [NCBI Gene 10736], CDH1 (cadherin 1) [NCBI Gene 999] {aka Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM}
- **Diseases:** Non-Small Cell Lung Cancer (MESH:D002289)

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Source: https://tomesphere.com/paper/PMC11216919