# Post-orgasmic Illness Syndrome: A Case Report

## TL;DR

A 25-year-old man with long-term flu-like symptoms after ejaculation was diagnosed with POIS and successfully treated with niacinamide.

## Contribution

This case report highlights the successful use of niacinamide therapy for managing POIS, a rare and poorly understood condition.

## Key findings

- Flu-like symptoms following ejaculation were diagnosed as post-orgasmic illness syndrome (POIS).
- Niacinamide therapy provided successful management of the patient's symptoms.
- The potential role of varicocele in symptom manifestation is suggested for further investigation.

## Abstract

Post-orgasmic illness syndrome (POIS) is a rare condition characterized by debilitating symptoms following ejaculation. We present a case of a 25-year-old male with flu-like symptoms post-ejaculation since age 17. Despite minimal relief from conventional treatments, a comprehensive evaluation led to the diagnosis of POIS and successful management with niacinamide therapy. The presentation of flu-like symptoms following ejaculation in this case raises several questions regarding the underlying pathophysiology. While the exact cause of his symptoms remains elusive, the resolution achieved with niacinamide therapy underscores the importance of considering alternative treatment modalities in complex cases. The role of varicocele in symptom manifestation, if any, also warrants consideration, as varicocele has been associated with male infertility and testicular dysfunction.