# Turn Up the Heat: A Case Report of Malignant Hyperthermia During Ambulatory Surgery

**Authors:** Alexander Luong, Vincent Relli-Dempsey, Elizabeth Johnson, Dyanni Price, Andrew Gable, Matthias J Franzen

PMC · DOI: 10.7759/cureus.61365 · Cureus · 2024-05-30

## TL;DR

A 67-year-old woman developed malignant hyperthermia during surgery despite having no known risk factors, and was successfully treated with dantrolene.

## Contribution

This case report highlights malignant hyperthermia occurrence in a patient without known predisposing factors.

## Key findings

- Malignant hyperthermia occurred in a patient with no personal or family history of anesthesia complications.
- Symptoms resolved after multiple doses of dantrolene and a week-long hospital stay.

## Abstract

Malignant hyperthermia is a rare complication of general anesthesia involving the uncontrolled release of calcium when exposed to triggers such as depolarizing muscle relaxants or volatile anesthetics. It presents as a hypercatabolic skeletal muscle syndrome that results in tachycardia, hyperthermia, hypercapnia, muscle rigidity, acidosis, rhabdomyolysis, and hyperkalemia. This report presents the case of a 67-year-old female without a personal or family history of complications with anesthesia who experienced malignant hyperthermia during an elective hysterectomy. The patient was given multiple doses of dantrolene, with the ultimate resolution of her symptoms several days after surgery. She was discharged one week after surgery.

## Linked entities

- **Chemicals:** dantrolene (PubChem CID 6914273)
- **Diseases:** malignant hyperthermia (MONDO:0018493)

## Full-text entities

- **Diseases:** acidosis (MESH:D000138), tachycardia (MESH:D013610), muscle rigidity (MESH:D009127), hypercapnia (MESH:D006935), hyperkalemia (MESH:D006947), Malignant Hyperthermia (MESH:D008305), hypercatabolic skeletal muscle syndrome (MESH:D005207), hyperthermia (MESH:D005334), rhabdomyolysis (MESH:D012206)
- **Chemicals:** dantrolene (MESH:D003620), calcium (MESH:D002118)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC11215928/full.md

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Source: https://tomesphere.com/paper/PMC11215928