# Variable Expression Common Immune Deficiency: A Report of Five Cases

## TL;DR

This paper reports five cases of common variable immunodeficiency, highlighting their symptoms, complications, and treatment with immunoglobulin infusions.

## Contribution

The paper contributes a case series of CVID with detailed clinical features and outcomes.

## Key findings

- All five patients had recurrent bronchopneumonitis and global hypogammaglobulinemia.
- Three patients developed bronchiectasis, and one required decortication due to purulent pleurisy.
- Monthly immunoglobulin infusions were used as treatment for all patients.

## Abstract

We present five cases of common variable immunodeficiency (CVID), comprising three women and two men with a mean age of 23.8 ± 9.2 years. All our patients suffered from recurrent bronchopneumonitis, with complications of purulent pleurisy in two cases, requiring decortication in one case, and resulting in bronchiectasis in three cases. Digestive tract infections were observed in four patients, while two patients presented with ENT infections. One case was complicated by bacterial meningitis. All patients presented with global hypogammaglobulinemia, with CVID and granulomatous manifestation in one case. Treatment consisted of monthly immunoglobulin infusions.