# A Case of Hepatic Tuberculosis in a Patient on Adalimumab for Ankylosing Spondylitis

**Authors:** Shayan Amini, Ronan Allencherril, Michelle Lin, Suzanne M Crumley, David W Victor

PMC · DOI: 10.7759/cureus.61264 · 2024-05-28

## TL;DR

This paper reports a rare case of liver tuberculosis in a patient taking adalimumab for ankylosing spondylitis.

## Contribution

The novelty lies in documenting hepatic TB in a patient on adalimumab, highlighting risks in immunosuppressed individuals.

## Key findings

- Hepatic TB is uncommon and often secondary to other TB sources.
- Immunosuppressive therapy, like adalimumab, increases the risk of TB.
- This case emphasizes the need for TB screening in patients on immunosuppressants.

## Abstract

Hepatic tuberculosis (TB) is an uncommon extrapulmonary manifestation of tuberculosis. Hepatic TB is more common in immunocompromised patients, such as those on immunosuppressive medications or those with a human immunodeficiency virus (HIV) infection. Primary hepatic TB is rare, and liver involvement is often secondary to spreading from the lymphatics, portal vein, or hepatic artery. We report a case of hepatic TB in a patient on adalimumab for ankylosing spondylitis (AS).

## Linked entities

- **Diseases:** hepatic tuberculosis (MONDO:0005787), ankylosing spondylitis (MONDO:0005306)

## Full-text entities

- **Diseases:** TB (MESH:D014376), AS (MESH:D013167), liver involvement (MESH:D017093), Hepatic TB (MESH:D014386), human immunodeficiency virus (HIV) infection (MESH:D015658)
- **Chemicals:** Adalimumab (MESH:D000068879)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11211017/full.md

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Source: https://tomesphere.com/paper/PMC11211017