# Anti-Ha Antisynthetase Syndrome: A Case Report

## TL;DR

This paper presents a rare case of anti-Ha antisynthetase syndrome in Brazil, a condition involving muscle, lung, and joint issues.

## Contribution

The first reported case of anti-Ha ASyS in Brazil, highlighting a rare autoimmune condition.

## Key findings

- Anti-Ha ASyS is a rare variant of anti-synthetase syndrome.
- The case was confirmed by the presence of anti-Ha autoantibodies.
- This is the first documented case of anti-Ha ASyS in Brazil.

## Abstract

Anti-synthetase syndrome (ASyS) is a rare systemic autoimmune myopathy characterized by the involvement of muscles, lungs, and joints, in addition to Raynaud’s phenomenon, “mechanics’ hand,” and fever. Laboratory ASyS is defined by the positivity of anti-aminoacyl-tRNA synthetase autoantibodies, of which anti-Jo-1 is the most common. Herein, we reported an ASyS defined by an anti-Ha autoantibody, which has rarely been described in the literature. Moreover, to the best of our knowledge, we reported the first case of anti-Ha ASyS in Brazil.