# Global and regional burden estimation of HIV-associated non-Hodgkin’s lymphoma: a meta-analysis and modelling analysis protocol

## TL;DR

This study aims to estimate how much HIV contributes to non-Hodgkin’s lymphoma cases globally and regionally using meta-analysis and modeling.

## Contribution

The study introduces a novel approach combining meta-analysis and PAF modeling to quantify the HIV-related NHL burden globally.

## Key findings

- The study will calculate pooled risk ratios to assess NHL risk in HIV-positive individuals.
- Population attributable fraction modeling will estimate the HIV-related NHL disease burden.
- Findings will include age-standardized rates and DALYs for global and regional analysis.

## Abstract

HIV infection is one of the complex aetiologies of non-Hodgkin’s lymphoma (NHL). However, the contribution of HIV to burden of NHL across time and region has not yet been comprehensively reported and quantified. Thus, this study aims to evaluate the relative risk of NHL in individuals with HIV infection compared with those without by performing a comprehensive meta-analysis. Additionally, we intend to further estimate quantitatively the degree of HIV contributing to burden of NHL using population attributable fraction (PAF) modelling analysis.

This study will screen a mass of records searched from four electronic databases (PubMed, Embase, Cochrane Library and Web of Science). The main outcomes are specific effect values and corresponding 95% CIs for NHL among population with HIV infection compared with those without to quantify the association between HIV infection and NHL. After quality assessment and data extraction, we will undertake a meta-analysis to calculate the pooled risk ratio (RR). Furthermore, PAF calculation based on pooled RR combines with number of age-specific disability-adjusted life year (DALY) and HIV prevalence data (aged ≥15 years old) from 1990 to 2019, at global, regional and country levels. We will calculate the PAF, HIV-associated DALY number and age-standardised rate to quantify the burden of HIV-associated NHL.

This study is based on published articles; thus, the ethic approval is not essential. In addition, we intend to publish the results on peer-reviewed journals for more discussion. We believe that research on estimating global burden of NHL can provide valuable insights for developing targeted prevention and control strategies, thereby achieving significant benefits.

CRD 42023404150.