Correction for: The p53/miR-17/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells
Wenjia Liu, Meng Qi, Anna Konermann, Liqiang Zhang, Fang Jin, Yan Jin
Abstract
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Taxonomy
TopicsMesenchymal stem cell research
Abbreviations: ALP: Alkaline phosphatase; BCA: Bicinchoninic acid; BMMSCs: Bone marrow mesenchymal stem cells; BMD: Bone mineral density; BMP: Bone morphogenetic protein; CFU-F/-Ob: Colony forming unit-fibroblast/-osteoblast; EDTA: Ethylenediaminetetraacetic acid; FBS: Fetal bovine serum; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; HE: Hematoxylin and eosin; HA/TCP: Hydroxyapatite/tricalcium phosphate; IFN-γ: Interferon gamma; MSC: Mesenchymal stem cell; miRNA: MicroRNA; α-MEM: Minimum Essential Medium α; PDLSC: Periodontal ligament stem cell; PBS: Phosphate buffered saline; PVDF: Polyvinylidene difluoride; Runx2: Runt-related transcription factor 2; Smurf1: Smad ubiquitin regulatory factor one; siRNA: Small interfering RNA; BV/TV: Trabecular bone volume fraction relative to tissue volume; TCF3: Transcription factor 3; MiRNA: microRNA; MTT: 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide; TNF-α: Tumor necrosis factor alpha.
This article has been corrected: The authors recently found that they used a non-representative image of Alizarin red staining in Figure 6E, “Alizarin red staining after osteogenic induction for 14 d of BMMSCs derived from old mice with/without siRNA-downregulated Smurf1 level and with/without transfection with miR-17 inhibitor.” They replaced panel 6E with the correct image of Alizarin red staining from the original experiments and state that this correction has no impact on the experimental outcome or conclusions. The authors would like to apologize for any inconvenience caused.
The authors also acknowledged that the email address of the corresponding author, Fang Jin, has been updated to [email protected].
The corrected version of Figures 6 is provided below.