# An Ultrasensitive Electrochemical Sensor Using Banana Peel Activated Carbon/NiFe2O4/MnCoFe-LDH Nanocomposites for Anticancer Drug Determination

## TL;DR

A new electrochemical sensor made from banana peel and metal compounds can detect a cancer drug with high accuracy in biological and pharmaceutical samples.

## Contribution

A novel nanocomposite sensor using banana peel activated carbon and metal oxides is developed for ultrasensitive detection of Palbociclib.

## Key findings

- The sensor has a wide linear range (0.01–13.0 μM) and a detection limit of 3.5 nM for Palbociclib.
- It achieves excellent recovery (98.5–102.9%) and low RSD (<3%) in real samples like urine and pharmaceuticals.
- The composite material enhances electrochemical performance with high electron transfer rates and surface area.

## Abstract

In the current study, we report the synthesis of a novel
composite
material composed of banana peel activated carbon (BPAC), nickel iron
oxide (NiFe2O4), and manganese cobalt iron layered
double hydroxide (MnCoFe-LDH) to create a high-performance electrochemical
sensor to detect Palbociclib (PLB). The composite was successfully
immobilized on a glassy carbon electrode (GCE) surface to create a
modified electrode. The performance of the electrode was thoroughly
evaluated, considering parameters such as electroactive surface areas
(ESA), electron transfer rate constant (k0), and exchange
current density (j0). The developed BPAC/NiFe2O4/MnCoFe-LDH/GCE exhibited a wide linear dynamic range
of 0.01–13.0 μM for PLB concentration, accompanied by
a detection limit at a low level (3.5 nM). Furthermore, it can be
applied to the determination of PLB in human urine and pharmaceutical
samples with excellent recoveries (98.5–102.9%) and RSD values
lower than 3%, establishing its potential for precise PLB determination
in pharmaceutical and biological samples. This research contributes
to the advancement of electrochemical sensor technology for the detection
of important anticancer drugs in real-world applications.