# The Effect of Iodinated Contrast Media Sensitivity on the Prognosis of Patients with STEMI

## TL;DR

This study found that sensitivity to iodinated contrast media does not significantly worsen outcomes for patients with STEMI.

## Contribution

The study is the first to investigate the impact of ICM sensitivity on STEMI prognosis using a large national database.

## Key findings

- ICM-sensitive patients had similar in-hospital mortality rates as non-sensitive patients.
- ICM-sensitive patients experienced less major bleeding during hospitalization.
- ICM-sensitive patients had comparable odds of MACCE as non-sensitive patients.

## Abstract

Background and Objectives: Iodinated Contrast Media (ICM) is used daily in many imaging departments worldwide. The main risk associated with ICM is hypersensitivity. When a severe hypersensitivity reaction is not properly managed and treated swiftly, it may be fatal. Currently, there is no data to demonstrate how ICM sensitivity affects the prognosis of cardiac patients, especially those diagnosed with ST elevation myocardial infarction (STEMI), in whom urgent coronary angiography is indicated. This study aimed to identify and characterize this relationship. Materials and Methods: We included patients hospitalized with STEMI between 2016 and 2019 from the National Inpatient Sample. The population was compared based on ICM sensitivity status, sensitive vs. non-sensitive. The primary endpoint was in-hospital mortality, with additional endpoints: length of stay and in-hospital complications. Results: The study included 664,620 STEMI patients, of whom 4905 (0.7%) were diagnosed with ICM sensitivity. ICM-sensitive patients were older, more often white, females, and had more comorbidities and cardiovascular risk factors. Both groups show similarities in management but are slightly less probable to undergo PCI or CABG. Multivariable logistic regression models found that the ICM-sensitive population had similar odds of in-hospital mortality (OR: 1.02, 95% CI: 0.89–1.16) and MACCE (OR: 1.05, 95% CI: 0.95–1.16), and less major bleeding (OR: 0.73, 95% CI: 0.60–0.87). Conclusions: Our study found that ICM sensitivity status was not a significant factor for worse prognosis in patients hospitalized with STEMI.