Comparative Review on Cancer Pathology from Aberrant Histone Chaperone Activity
Jiho Lee, Xiucong Bao
TL;DR
This review explores how abnormal histone chaperone activity contributes to cancer and highlights their potential as targets for new cancer therapies.
Contribution
The paper systematically reviews the role of histone chaperones in cancer pathogenesis and their potential as therapeutic targets.
Findings
Dysregulation of histone chaperones is linked to tumorigenesis and cancer progression.
Altered histone chaperone activity correlates with genomic instability and oncogenic processes.
Histone chaperones are viable targets for precision cancer therapies.
Abstract
Histone chaperones are integral to chromatin dynamics, facilitating the assembly and disassembly of nucleosomes, thereby playing a crucial role in regulating gene expression and maintaining genomic stability. Moreover, they prevent aberrant histone interactions prior to chromatin assembly. Disruption in histone chaperone function may result in genomic instability, which is implicated in pathogenesis. This review aims to elucidate the role of histone chaperones in cancer pathologies and explore their potential as therapeutic targets. Histone chaperones have been found to be dysregulated in various cancers, with alterations in expression levels, mutations, or aberrant interactions leading to tumorigenesis and cancer progression. In addition, this review intends to highlight the molecular mechanisms of interactions between histone chaperones and oncogenic factors, underscoring their roles…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsGenomics and Chromatin Dynamics · Ubiquitin and proteasome pathways · Protein Degradation and Inhibitors