Efficacy of Human Recombinant Growth Hormone in Females of a Non-Obese Hyperglycemic Mouse Model after Birth with Low Birth Weight
Wataru Tokunaga, Nobuhiko Nagano, Kengo Matsuda, Kimitaka Nakazaki, Shoichi Shimizu, Koh Okuda, Ryoji Aoki, Kazumasa Fuwa, Hitohiko Murakami, Ichiro Morioka
TL;DR
This study shows that growth hormone improves insulin resistance in female mice born with low birth weight by increasing type 1 muscle fibers and enhancing liver mitochondrial function.
Contribution
The study demonstrates a novel therapeutic effect of GH on insulin resistance in a non-obese hyperglycemic mouse model with low birth weight.
Findings
GH treatment improved the insulin resistance index in the Ischemia-GH group compared to the Ischemia group.
GH increased the percentage of type 1 muscle fibers and altered muscle fiber type.
GH reduced oxidative stress and increased ATP production in the liver, indicating improved mitochondrial function.
Abstract
We examined whether the administration of growth hormone (GH) improves insulin resistance in females of a non-obese hyperglycemic mouse model after birth with low birth weight (LBW), given that GH is known to increase muscle mass. The intrauterine Ischemia group underwent uterine artery occlusion for 15 min on day 16.5 of gestation. At 4 weeks of age, female mice in the Ischemia group were divided into the GH-treated (Ischemia-GH) and non-GH-treated (Ischemia) groups. At 8 weeks of age, the glucose metabolism, muscle pathology, and metabolome of liver were assessed. The insulin resistance index improved in the Ischemia-GH group compared with the Ischemia group (p = 0.034). The percentage of type 1 muscle fibers was higher in the Ischemia-GH group than the Ischemia group (p < 0.001); the muscle fiber type was altered by GH. In the liver, oxidative stress factors were reduced, and ATP…
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Taxonomy
TopicsBirth, Development, and Health · Diet and metabolism studies · Growth Hormone and Insulin-like Growth Factors