Design of Apoptotic Cell-Inspired Particles as a Blood Coagulation Test
Liang Yue, Yasuhiro Nakagawa, Mitsuhiro Ebara
TL;DR
Researchers developed new particles inspired by apoptotic cells to improve blood coagulation tests, offering a stable and controllable alternative to current methods.
Contribution
The creation of apoptotic cell-inspired MPS particles as a novel and stable alternative to conventional APTT reagents for coagulation testing.
Findings
MPS particles showed stable coagulation ability across different temperatures.
Procoagulant activity increased with higher particle concentration and smaller size.
Fibrin clots formed by MPS particles were comparable to those formed by Actin FSL.
Abstract
The blood coagulation test is an indispensable test for monitoring the blood coagulation and fibrinolysis functions. Currently, activated partial thromboplastin time (APTT) is the most widely used approach to coagulation testing. However, APTT reagents need to be optimized due to the fact that they are unstable, highly variable, and cannot be easily controlled. In this study, we created apoptotic cell-inspired methacryloyloxyethyl phosphorylserine (MPS) particles for blood coagulation as an alternative to conventional APTT reagents. Particle size could be controlled by changing the concentration of the polymer. The blood coagulation ability of particles was stable at different environmental temperatures. Moreover, the procoagulant activity could be enhanced by increasing the concentration to 0.06 mg/mL and reducing the size of the particles to around 900 nm. Fibrin clotted by particles…
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Taxonomy
TopicsPhagocytosis and Immune Regulation · Blood Coagulation and Thrombosis Mechanisms · Platelet Disorders and Treatments