# Exosomal noncoding RNAs: decoding their role in thyroid cancer progression

## TL;DR

This paper reviews how non-coding RNAs in exosomes contribute to thyroid cancer progression and their potential as biomarkers and therapeutic tools.

## Contribution

The paper systematically reviews the role of exosomal non-coding RNAs in thyroid cancer mechanisms and their clinical potential.

## Key findings

- Exosomal non-coding RNAs regulate key cancer processes like proliferation and metastasis in thyroid cancer.
- Exosomal ncRNAs are stable in plasma, making them promising diagnostic and prognostic biomarkers.
- Exosomes offer therapeutic potential by delivering ncRNAs that modulate oncogenic pathways.

## Abstract

Exosomes, as pivotal entities within the tumor microenvironment, orchestrate intercellular communication through the transfer of diverse molecules, among which non-coding RNAs (ncRNAs) such as miRNAs, lncRNAs, and circRNAs play a crucial role. These ncRNAs, endowed with regulatory functions, are selectively incorporated into exosomes. Emerging evidence underscores the significance of exosomal ncRNAs in modulating key oncogenic processes in thyroid cancer (TC), including proliferation, metastasis, epithelial-mesenchymal transition (EMT), angiogenesis, and immunoediting. The unique composition of exosomes shields their cargo from enzymatic and chemical degradation, ensuring their integrity and facilitating their specific expression in plasma. This positions exosomal ncRNAs as promising candidates for novel diagnostic and prognostic biomarkers in TC. Moreover, the potential of exosomes in the therapeutic landscape of TC is increasingly recognized. This review aims to elucidate the intricate relationship between exosomal ncRNAs and TC, fostering a deeper comprehension of their mechanistic involvement. By doing so, it endeavors to propel forward the exploration of exosomal ncRNAs in TC, ultimately paving the way for innovative diagnostic and therapeutic strategies predicated on exosomes and their ncRNA content.