# Therapeutic apheresis: is it safe in children with kidney disease?

## TL;DR

This study examines the safety of therapeutic apheresis in children with kidney disease, finding it to be generally safe with a low complication rate.

## Contribution

The study provides new insights into the safety profile of therapeutic apheresis in pediatric nephrology patients.

## Key findings

- Complications occurred in 4.8% of therapeutic apheresis sessions in children with kidney disease.
- Technical complications, particularly insufficient flow, were the most common type of issue.
- Children aged 3–6 years had a higher incidence of complications compared to other age groups.

## Abstract

Therapeutic apheresis (TA) is already used to treat various diseases in the field of nephrology. The aim of this study was to evaluate the frequency and types of complications that occur during TA in children with kidney disease.

Records of children (≤ 18 years) who underwent TA between 2007 and 2022 were retrospectively reviewed. Children with missing data and those with a diagnosis of nonnephrological disease were excluded.

A total of 1214 TA sessions, including 1147 therapeutic plasma exchange (TPE) sessions and 67 immunoadsorption (IA) sessions, were performed on the 108 patients enrolled in the study. Forty-seven percent of the patients were male, and the mean age was 12.22 ± 4.47 years. Posttransplant antibody-mediated rejection (64.8%) and hemolytic uremic syndrome (14.8%) were the most common diagnoses indicating TA. Overall, 17 different complications occurred in 58 sessions (4.8%), and 53 sessions (4.6%) were not completed because of these complications. The distribution of complications among the patients was as follows: 41.4% had technical complications, 25.9% had allergic complications, and 32.7% had others. The most common technical complication was insufficient flow (37.5%). The incidence of complications was greater in patients aged 3–6 years than in patients in the other age groups (p = 0.031). The primary disease, type of vascular access, and rate of fresh frozen plasma/albumin use were similar between patients with and without complications (p values of 0.359 and 0.125 and 0.118, respectively).

Our study showed that complications occurred in only 4.8% of TA sessions. The most common complication was technical problems.

A higher resolution version of the Graphical abstract is available as Supplementary information

A higher resolution version of the Graphical abstract is available as Supplementary information

The online version contains supplementary material available at 10.1007/s00467-024-06346-0.