# Pleomorphic Carcinoma of the Breast: A Report of Three Cases

## TL;DR

This paper reports three cases of a rare and aggressive breast cancer called pleomorphic carcinoma, highlighting its unique cellular features and clinical significance.

## Contribution

The study contributes new clinical and pathological insights into pleomorphic carcinoma of the breast through case reports and a literature review.

## Key findings

- Three cases of pleomorphic carcinoma were identified with large pleomorphic cells and multinucleated giant cells.
- Immunohistochemical analysis showed distinct profiles in the malignant components of each case.
- The tumor's unique features emphasize the need for specific clinical considerations in diagnosis and management.

## Abstract

Pleomorphic carcinoma (PC) is an uncommon and high-grade form of breast carcinoma characterized by the presence of distinctive pleomorphic giant tumor cells exhibiting bizarre nuclei and atypical mitosis.

In this study, we report three patients who presented with lesions composed of a proliferation of large pleomorphic cells with a predominance of multinucleated giant cells on a microscope. Immunohistochemical analysis revealed distinct immunologic profiles within the respective malignant components. Notably, this report aims to contribute valuable insights, adding to the understanding of this uncommon tumor, accompanied by a literature review.

Despite its rarity, PC in the breast remains clinically relevant due to its distinctive morphological and pathological features. These unique attributes require specific considerations in both clinical presentation and management.