Beware the glowing fat: pericarditis pitfall

Abstract

Figures

A](#qyae036-F1)*).^[3](#qyae036-B3)^ Fat usually exhibits a hyperintense signal during the inversion time optimized to null the myocardial signal. LGE sequences with fat saturation are proving particularly useful in this context (*[Figure 1B](#qyae036-F1)*), enabling more accurate characterization of true pericardial enhancement (*[Figure 1C](#qyae036-F1)*). In situations lacking fat-saturated LGE sequences, Dixon-type sequences (*[Figure 1D](#qyae036-F1)*), though not gated, offer an alternative by subtracting fat signal to detect pericardial enhancement. MRI assessment of the pericardium is

Full text

Pericardial inflammation in acute and recurrent pericarditis induces increased vascularity, neutrophil infiltration, and fibrin deposition that, in turn, can be detected by magnetic resonance imaging (MRI) using late gadolinium enhancement (LGE) sequences.^1^ A recent study presented by Cremer et al. elucidated the role of cardiac MRI in assessing recurrent pericarditis and its potential impact on rilonacept treatment duration.^2^ The authors aptly demonstrated the significance of pericardial LGE in predicting the frequency and timing of pericarditis recurrence, emphasizing the importance of tailored therapeutic strategies based on MRI findings.

Phase-sensitive inversion recovery sequences with an inversion time selected for optimal myocardial nulling were used to detect and grade pericardial LGE in the RHAPSODY trial.^2^ However, I would like to point out that while LGE sequences are sensitive to inflammatory and fibrotic changes, their original design without fat saturation may inadvertently highlight epicardial fat, mimicking enhancement (Figure 1A).^3^ Fat usually exhibits a hyperintense signal during the inversion time optimized to null the myocardial signal. LGE sequences with fat saturation are proving particularly useful in this context (Figure 1B), enabling more accurate characterization of true pericardial enhancement (Figure 1C). In situations lacking fat-saturated LGE sequences, Dixon-type sequences (Figure 1D), though not gated, offer an alternative by subtracting fat signal to detect pericardial enhancement. MRI assessment of the pericardium is becoming increasingly common, and a comprehensive understanding of tissue behaviour across different sequences is critical for accurate interpretation of imaging findings.

Lead author biography

André Vaz is a cardiovascular radiologist based in São Paulo, Brazil. He completed his Fellowship in Cardiovascular CT and MRI at the Instituto do Coração do Hospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, under the supervision of Carlos Eduardo Rochitte. Prior to this, he earned a Master’s Degree in Internal Medicine from the Universidade Federal do Paraná and completed fellowships in Pediatric Radiology at Hospital Pequeno Príncipe. He obtained his Doctor of Medicine degree from the Universidade Federal de Santa Catarina. He is currently involved in research into congenital heart disease, 3D printing, and genetic cardiomyopathies.