# Sertraline Hydrochloride Overdose Resulting in Diabetes Insipidus: A Case Report

## TL;DR

A 17-year-old girl developed diabetes insipidus after a sertraline overdose and was successfully treated with pituitrin.

## Contribution

This case report highlights a rare side effect of sertraline overdose causing diabetes insipidus.

## Key findings

- A single high dose of sertraline hydrochloride led to diabetes insipidus in a 17-year-old female.
- Symptoms were effectively managed with pituitrin treatment.

## Abstract

Sertraline hydrochloride belongs to the selective serotonin reuptake inhibitor class of antidepressants, which can cause respiratory depression, hypotension, malignant vomiting, liver function impairment, and other symptoms when taken in excess. To our knowledge, reports of sertraline hydrochloride overdose causing diabetes insipidus in patients are rare. This report describes a unique case of a 17-year-old female patient who developed diabetes insipidus after a one-time oral intake of 20 sertraline hydrochloride tablets (50 mg/tablet) during the later course of treatment. Her symptoms were effectively relieved after treatment with pituitrin.