# Breast Metastasis From Cutaneous Melanoma: Beyond the Infiltrating Ductal Carcinoma

**Authors:** Marisol Ramos Portales, Carmen G Bermúdez Barrientos, Nishdaly A Rodríguez Valencia, Brizio Moreno Jaime

PMC · DOI: 10.7759/cureus.60931 · Cureus · 2024-05-23

## TL;DR

This paper discusses a rare case of breast metastasis from cutaneous melanoma and highlights the challenges in diagnosing and treating such cases.

## Contribution

The paper presents a unique clinical case emphasizing the importance of thorough history and high suspicion in diagnosing rare breast metastases.

## Key findings

- Breast metastases from cutaneous melanoma are rare and challenging to diagnose.
- An extensive clinical history and suspicion are crucial for accurate diagnosis and treatment planning.

## Abstract

Breast metastases of extramammary origin are an extremely rare entity. Solid organ metastases to the breast include malignant melanoma, epithelial carcinoma (adenocarcinoma and squamous cell carcinoma of the lung and gastrointestinal tract), and sarcoma. A breast neoplasm can be caused by a primary tumor, in-transit metastasis, breast metastasis, and skin metastasis. A 42-year-old female patient presented with a hyperpigmented lesion on the first finger of her left hand. An incisional biopsy was carried out, reporting pigmented epithelioid melanoma. Amputation of the finger was performed, as well as an axillary sentinel lymph node excision. Later during the treatment and follow-up by medical oncology, a breast tumor was located, followed by a protocol and the approach of possible differential diagnoses. Finally, it was characterized as metastatic cutaneous melanoma. The therapeutic approach regarding the possible origin of the metastatic neoplastic character of breast tumors culminated in this case in the palliative treatment with immunotherapy of cutaneous malignant melanoma. The diagnosis of breast metastases from cutaneous malignant melanoma is a real challenge, so an extensive history and high clinical suspicion are crucial in order to provide adequate treatment, despite the gloomy prognosis.

## Linked entities

- **Diseases:** cutaneous melanoma (MONDO:0005012)

## Full-text entities

- **Diseases:** Ductal Carcinoma (MESH:D044584), malignant melanoma (MESH:D008545), hyperpigmented lesion (MESH:C537836), Breast Metastasis (MESH:D061325), Cutaneous Melanoma (MESH:C562393), epithelial carcinoma (MESH:D009375), adenocarcinoma (MESH:D000230), metastases (MESH:D009362), sarcoma (MESH:D012509), breast neoplasm (MESH:D001943), squamous cell carcinoma of the lung and gastrointestinal tract (MESH:D002294), tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

10 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11193477/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC11193477/full.md

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Source: https://tomesphere.com/paper/PMC11193477