# Systemic Capillary Leak Syndrome as a Paraneoplastic Syndrome

## TL;DR

This paper presents a rare case where a blood vessel disorder revealed a previously undiagnosed B-cell lymphoma.

## Contribution

The novelty is the presentation of SCLS as a paraneoplastic syndrome revealing a large B-cell lymphoma.

## Key findings

- SCLS can be a paraneoplastic syndrome associated with non-Hodgkin lymphoma.
- The case highlights SCLS as a rare initial manifestation of B-cell lymphoma.
- SCLS is uncommonly linked to cancer, particularly B-cell origin lymphomas.

## Abstract

Systemic capillary leak syndrome (SCLS) is a rare entity that is frequently idiopathic or, rarely, associated with infections, autoimmune diseases, drugs, surgery, and cancer. Several cancers can directly cause SCLS, although it is very uncommon as the inaugural presentation of a non-Hodgkin lymphoma. We report a case of SCLS as a paraneoplastic syndrome which revealed a large B-cell lymphoma, a non-Hodgkin lymphoma of B-cell origin.