# Clinical Characteristics of Migraine and Their Association With the Retinal Nerve Fiber Layer Thickness

## TL;DR

This study found no significant difference in retinal nerve fiber layer thickness between migraine patients and controls, but longer migraine duration was linked to changes in retinal thickness.

## Contribution

The study reveals a novel correlation between the duration of migraine and retinal nerve fiber layer thickness.

## Key findings

- RNFL thickness showed no significant difference between migraine patients and controls.
- Migraine duration correlated significantly with superior RNFL thickness in both eyes and inferior RNFL in the right eye.
- Headache attack duration correlated with superior retinal RNFL thickness.

## Abstract

Background: Migraine is characterized by recurrent episodes of unilateral, pulsating headaches. At the cerebral and ocular levels, it is recognized that the vascular narrowing and loss of blood flow are transient; however, the chronic nature of migraine may result in long-term functional and structural changes in these structures. It could result in axonal loss and an alteration in the thickness of the retinal nerve fiber layers (RNFL). This study aimed to measure the RNFL thickness, which provides a useful indication of the state of the axons and the loss of ganglion cells in migraine patients, and to find out if RNFL thickness and the clinical features of migraine are correlated.

Materials and methods: Sixty patients with migraine and 60 age-gender-matched controls were recruited. A complete neurological and ophthalmological examination was performed, and spectral-domain optical coherence tomography (SD-OCT) was done to measure RNFL.

Results: All quadrants of the retina on both sides showed non-statistically significant differences in RNFL thickness between migraine patients and controls (p-value >0.05). Furthermore, in all retinal quadrants on both sides, there was no statistically significant difference in RNFL thickness between migraine patients with aura and those without aura (p-value >0.05). Significant correlations were found between the duration of migraine disease and the superior RNFL thickness of both eyes, as well as the inferior RNFL in the right eye. There was also a significant correlation between the headache attack duration and RNFL thickness of the superior retina (p<0.05),

Conclusion: Our key finding was that when comparing migraine patients to controls, RNFL thickness did not significantly change; however, the duration of migraine disease did significantly affect RNFL thickness.