# Rapidly Progressive Apical Hypertrophic Cardiomyopathy: Not Everything is What It Seems

**Authors:** Ahmed K. Mahmoud, Juan M. Farina, Kamal Awad, Milagros Pereyra, Isabel G. Scalia, Mohammed Tiseer Abbas, Timothy Barry, Said Alsidawi, Chadi Ayoub, Reza Arsanjani

PMC · DOI: 10.14797/mdcvj.1386 · 2024-06-21

## TL;DR

A 43-year-old woman with a kidney transplant and hypertension developed a rare and rapidly progressing form of apical hypertrophic cardiomyopathy, showing unique diagnostic challenges.

## Contribution

This case report presents a rare instance of rapidly progressive apical HCM with distinctive clinical and diagnostic features.

## Key findings

- The patient exhibited characteristic ECG findings of giant T-wave inversions.
- Cardiac MRI confirmed apical hypertrophy with circumferential thickening.
- The case emphasizes the difficulty in diagnosing rapidly progressive apical HCM.

## Abstract

Apical hypertrophic cardiomyopathy (HCM) is a rare variant of HCM. A 43-year-old female with a past medical history significant for hypertension and kidney transplantation presented with recurrent syncopal episodes and dyspnea on exertion. Electrocardiogram showed characteristic diffuse giant T-waves inversion, and cardiac magnetic resonance showed HCM with circumferential apical thickening. This case highlights the rapid development of apical HCM and its challenging diagnostic characteristics.

## Linked entities

- **Diseases:** hypertrophic cardiomyopathy (MONDO:0005045)

## Full-text entities

- **Diseases:** hypertension (MESH:D006973), HCM (MESH:D002312), dyspnea (MESH:D004417), Apical Hypertrophic Cardiomyopathy (MESH:D000092183), syncopal episodes (MESH:D013575)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11192092/full.md

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Source: https://tomesphere.com/paper/PMC11192092