Risk factors for mortality in culture-negative neonatal sepsis in Malawi: a propensity score-matched analysis

TL;DR

This study identifies risk factors for death in newborns with culture-negative sepsis in Malawi, highlighting the importance of maternal and perinatal care.

Contribution

The study uses a propensity score-matched analysis to identify specific risk factors for mortality in culture-negative neonatal sepsis in Malawi.

Findings

Very low birth weight significantly increases mortality risk in culture-negative neonatal sepsis.

Respiratory distress syndrome is strongly associated with higher mortality rates in affected neonates.

Low Apgar scores at 1 and 5 minutes are significant predictors of mortality in these cases.

Abstract

We conducted a propensity score-matched multivariable regression analysis of 1050 culture-negative neonatal sepsis cases in Malawi, where 160 (15.2%) died. Mortality among neonates with culture-negative sepsis was associated with very low birth weight (adjusted OR (AOR) 12.82, 95% CI 1.23 to 137.49), respiratory distress syndrome (AOR 13.20, 95% CI 2.58 to 83.66), a low Apgar score at 1 min (AOR 3.50, 95% CI 1.21 to 10.72) and at 5 min (AOR 4.77, 95% CI 1.94 to 12.50). Addressing maternal and perinatal factors around health and delivery of care is key to improving outcomes in the context of culture-negative sepsis in neonates from low-income country settings like Malawi.