Analysis of long non-coding RNA RMRP in the diagnosis and prognosis of coronary artery disease

TL;DR

This study shows that high levels of a specific RNA (RMRP) in blood are linked to worse heart disease severity and outcomes in patients with coronary artery disease.

Contribution

The study identifies serum RMRP as a novel biomarker for assessing CAD severity and predicting prognosis.

Findings

Serum RMRP levels are significantly higher in CAD patients compared to healthy individuals.

High RMRP is associated with increased SYNTAX scores and higher risk of adverse cardiovascular events.

RMRP is an independent risk factor for major adverse cardiovascular events in CAD patients.

Abstract

Long non-coding RNAs (lncRNAs) are abundant and closely related to the occurrence and development of human diseases. LncRNAs are known to play a key role in many cardiovascular diseases. The purpose of this study was to investigate the effect of the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP) on the degree of coronary artery lesions and prognosis in patients with coronary artery disease (CAD).

Patients who underwent coronary angiography (CAG) and dynamical-single photon emission computed tomography (D-SPECT) were selected as study subjects, and the results of CAG were reviewed, and the patients were grouped according to SYNTAX score. Evaluate the factors affecting SYNTAX scores. The follow-up analysis was conducted, and the endpoint events were major adverse cardiovascular events (MACEs). Kaplan–Meier method was used to estimate the survival rate, and multivariate Cox regression was used to analyze the relationship between RMRP and MACEs.

The expression level of serum RMRP in patients with CAD was significantly higher than that in healthy people. Multivariate Logistic regression analysis showed that age, low-density lipoprotein cholesterol (LDL-C), RMRP and rest left ventricular ejection fraction (LVEF) were independent factors that affected SYNTAX scores. There were 19 cases of MACEs in the high RMRP group and 9 cases in the low RMRP group, and there was a significant difference in the MACE free survival curve between the two groups. Multivariate Cox regression analysis showed that age, SYNTAX score, rest LVEF and RMRP were risk factors for MACEs.

Serum RMRP is a key factor affecting the degree of coronary artery disease and prognosis in CAD patients.

Figures