Differential expression and clinical significance of long non-coding RNAs in the development and progression of lung adenocarcinoma
Haitao Wei, Sa Zhang, Xiaojin Lin, Ruirui Fang, Li Li
TL;DR
This paper reviews how long non-coding RNAs (lncRNAs) influence lung adenocarcinoma development and could aid in early diagnosis and treatment.
Contribution
The paper compiles current knowledge on lncRNA roles in lung adenocarcinoma and highlights their potential as diagnostic and therapeutic targets.
Findings
LncRNAs can act as oncogenes or tumor suppressors in lung adenocarcinoma.
Differential lncRNA expression affects tumor progression and patient survival.
LncRNAs offer potential as early diagnostic markers for lung adenocarcinoma.
Abstract
With the development of gene testing technology, we have found many different genes, and lncRNA is one of them. LncRNAs refer to a non-protein coding RNA molecule with a length of more than 200bp, which is one of the focuses of research on human malignant diseases such as LUAD. LncRNAs act as an oncogene or inhibitor to regulate the occurrence and progression of tumors. The differential expression of LncRNAs promotes or inhibits the progression of lung adenocarcinoma by affecting cell proliferation, metastasis, invasion, and apoptosis, thus affecting the prognosis and survival rate of patients. Therefore, LncRNAs can be used as a potential target for diagnosis and treatment of cancer. The early diagnosis of the disease was made through the detection of tumor markers. Because lung adenocarcinoma is not easy to diagnose in the early stage and tumor markers are easy to ignore, LncRNAs play…
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Taxonomy
TopicsCancer-related molecular mechanisms research · Circular RNAs in diseases · RNA modifications and cancer