# Transgradient Variant of Mal De Meleda Presenting As Palmoplantar Keratoderma: A Case Report

## TL;DR

This case report describes an 18-year-old with a rare skin condition called transgradiens variant of Mal De Meleda and shows successful treatment with acitretin and moisturizers.

## Contribution

The paper presents a rare transgradiens variant of Mal De Meleda and demonstrates effective treatment with oral acitretin.

## Key findings

- The patient showed thickened, yellowish skin on palms and soles with itching and cracking.
- Treatment with oral acitretin and topical moisturizers led to significant clinical improvement.
- The case emphasizes the need for multidisciplinary management of rare keratoderma variants.

## Abstract

Mal De Meleda is a rare genetic disorder characterized by palmoplantar keratoderma, often presenting challenges in diagnosis and management. This case report discusses an 18-year-old male presenting with thickened, yellowish skin on both palms and soles, accompanied by itching and cracking. A diagnosis of the transgradiens variant of Mal De Meleda was established through clinical and histopathological examination. Treatment with oral acitretin and topical moisturizers resulted in significant improvement. This report highlights the importance of recognizing rare variants of palmoplantar keratoderma and the need for a multidisciplinary approach to diagnosis and management.