# A Case of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia in a 26-Year-Old Pregnant Woman

**Authors:** Natalie Shaykh, Falguni Patel, Luke Stachler, Kabeer Ali, Vanshika Tripathi, Oshin Rai, Rafik Jacob

PMC · DOI: 10.7759/cureus.60679 · Cureus · 2024-05-20

## TL;DR

This paper presents a rare case of a 26-year-old pregnant woman diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia.

## Contribution

The paper highlights the unique challenges and multi-disciplinary treatment approach for Ph+ ALL in a young pregnant patient.

## Key findings

- Ph+ ALL is rare in young adults and even rarer during pregnancy.
- A multi-disciplinary approach is essential for managing Ph+ ALL in unique demographic cases.
- The case emphasizes the need for tailored treatment strategies in atypical patient populations.

## Abstract

Acute lymphoblastic leukemia (ALL) is an uncommon and rapidly progressing blood cancer originating in the bone marrow, characterized by the abnormal proliferation of immature lymphocytes. Although most cases of ALL are observed in children, the disease pattern shows two peaks: one in early childhood and another around the age of 50. Approximately a fifth to a third of adults diagnosed with ALL exhibit cytogenetic abnormalities involving the Philadelphia chromosome. Despite the existence of several studies on Philadelphia chromosome-positive ALL (Ph+ ALL), our case accentuates the use of a multi-disciplinary approach to treatment and involves a patient from a unique demographic.

## Linked entities

- **Diseases:** acute lymphoblastic leukemia (MONDO:0004967)

## Full-text entities

- **Diseases:** Philadelphia Chromosome (MESH:D010677), blood cancer (MESH:D019337), ALL (MESH:D054198), cytogenetic abnormalities (MESH:D002869)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC11187471/full.md

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Source: https://tomesphere.com/paper/PMC11187471