Screening of poly-beta amino ester coated emulsion of ketorolac for cartilage delivery
Tahani Saeedi, Polina Prokopovich
TL;DR
This study explores using PBAE-coated emulsions to deliver ketorolac for osteoarthritis treatment, showing improved drug retention and cartilage protection.
Contribution
A systematic screening of PBAE polymers for emulsion-based drug delivery to cartilage is presented.
Findings
PBAE-coated emulsions enhanced drug localization in ex vivo cartilage models.
Optimal PBAE candidates protected chondrocyte viability and increased GAG and collagen contents in damaged cartilage.
Abstract
Osteoarthritis (OA) is a prevalent chronic health condition necessitating effective treatment strategies. Globally, there were 86 million people with incident knee osteoarthritis in 2020. Pain management remains the primary approach to OA as the nature of cartilage poses challenges for drug delivery. An emulsion-based delivery system, using a class of positively charged and hydrolysable polymers (poly-beta-amino-esters) to coat oil droplets containing drugs, has been shown to enhance and prolong drug localization in ex vivo cartilage models. As the properties of the polymers used in this technology strongly depend on the monomers used in the synthesis, this study presents the screening of a wide range of PBAEs as droplet coating agents and using ketorolac as a model of nonsteroidal anti-inflammatory drugs. The emulsions prepared with this PBAE library were characterized, and drug…
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Taxonomy
TopicsOsteoarthritis Treatment and Mechanisms · Inflammatory mediators and NSAID effects · Proteoglycans and glycosaminoglycans research