A case of renal sarcoidosis complicated by parotid gland and uterine lesions

TL;DR

A rare case of sarcoidosis affecting the kidneys, parotid glands, and uterus is reported, with successful treatment using prednisolone.

Contribution

This is the first documented case of sarcoidosis involving the kidneys, parotid glands, and uterus simultaneously.

Findings

Renal biopsy and cytological evaluations confirmed sarcoidosis in the kidneys, parotid glands, and uterus.

Treatment with prednisolone improved renal dysfunction and reduced swelling in the parotid glands and uterus.

Ga scintigraphy confirmed the presence and subsequent resolution of sarcoid lesions in the affected organs.

Abstract

Sarcoidosis is a systemic disease that can affect multiple organs. While pulmonary sarcoidosis is most commonly observed, renal sarcoidosis occurs less frequently. We herein report a case of sarcoidosis with an exceptionally rare distribution including renal lesions.

A 51-year-old Japanese female was referred because of bilateral parotid swelling and renal dysfunction. Computed tomography scan showed the swelling of bilateral kidneys, parotid glands, and uterus. Ga scintigraphy also showed remarkable accumulation in these organs. Renal biopsy and cytological evaluations of parotid gland and uterus were performed and she was diagnosed as sarcoidosis of these organs. Treatment was initiated with prednisolone 40 mg/day and then renal dysfunction subsequently improved. In addition, the swelling of parotid glands and uterus improved and Ga accumulation in each organ had disappeared.

This is a first case of renal sarcoidosis complicated by parotid glands and uterus lesions. Pathological findings and the reactivity observed in Ga scintigraphy indicated the presence of lesions in these organs.

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